Application of 60025-09-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To the solution of 44 (200 mg, 0.664 mmol, 1.1 eq) in t-BuOH(4 mL) were added 6-chloro-9H-purine (93 mg, 0.604 mmol, 1.0 eq)and DIPEA (149 mL, 0.906 mmol, 1.5 eq). The resultant mixture was stirred at 80 C under N2 atmosphere for 8 h and concentrated in vacuo. To the residue was added DCM, and the mixture was washed successively with saturated NaHCO3 solution, dilute hydrochloric acid (0.5 N) and brine. The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. Flash column chromatography utilizing EA/PE (1:1e3:1) and EA/AcOH (80:1) as the eluent afforded a light yellow oil. It was then dissolved in DCM, and the resulting solution was washed successively with saturated NaHCO3 solution, brine, dried over anhydrous Na2SO4, and concentrated in vacuo to afford 3-(1-((9H-purin-6-yl)amino)ethyl)-2-phenyl-2Hbenzo[e][1,2,4]thiadiazine 1,1-dioxide 55 as a light yellow solid.Yield 28%;
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile.
Reference:
Article; Ma, Xiaodong; Wei, Jun; Wang, Chang; Gu, Dongyan; Hu, Yongzhou; Sheng, Rong; European Journal of Medicinal Chemistry; vol. 170; (2019); p. 112 – 125;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia