Adding a certain compound to certain chemical reactions, such as: 6693-08-9, 2,4,6-Trichloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6693-08-9, blongs to pyrimidines compound. SDS of cas: 6693-08-9
Intermediate 64-(2,6-Dichloro-5-fluoropyrimidin-4-yl)morpholineA round-bottom flask was charged with 2,4,6-trichloro-5-fluoropyrimidine (WO200549033, 2.0 g, 10 mmol), in EtOH (100ml) and was cooled to -200C. Morpholine (0.95 g, 11 mmol) in EtOH (20 ml) was added drop-wise to the reaction mixture in the course of 1 hour. The reaction was stirred at -200C for 30 minutes and at room temperature overnight. Solvent was removed under reduced pressure and the residue was partitioned between DCM and H2O. Organic phase was concentrated under reduced pressure to give a solid. Recrystallization from EtOH afforded the title compound (1.75 g, 86%). 1U NMR (delta) 6.76 (s, IH), 3.69 (m, 8H). LCMS: 252 [M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6693-08-9, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/132502; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia