Application of 81765-97-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 81765-97-1, name is 4-Chloro-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine, molecular formula is C11H11ClN2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: The different 4-chloro-thieno[2,3-d]pyrimidine (7a-d or f-i) (1 eq.) was suspended in MeOH (5.1mL/mmol eq.) and hydrazine hydrate 80percent in water (2 eq.) and the mixture was refluxed for 5 h. Immediately after, hydrazine hydrate (2 eq.) was added to complete the reaction and the mixture was allowed to reflux for further 3 h. The reaction mixture was then cooled to r.t and placed in a fridge o.n. The resulting precipitate was filtered and crystallised from a solution of 40percent EtOH in water unless otherwise stated.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 81765-97-1, 4-Chloro-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine.
Reference:
Article; Bassetto, Marcella; Leyssen, Pieter; Neyts, Johan; Yerukhimovich, Mark M.; Frick, David N.; Brancale, Andrea; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 31 – 47;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia