Related Products of 875251-47-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 875251-47-1, name is 2-(Pyrimidin-5-yl)ethanol, molecular formula is C6H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 5-[4-(trifluoromethoxy)phenyl]-3H-oxazolo[4,5-b]pyridin-2-one (100 mg, 0.34 mmol), 2-pyrimidin-5-ylethanol (125.73 mg, 1.01 mmol) in THF (10 mL) was added PPh3 (177.1 mg, 0.68 mmol) and DIAD (136.54 mg, 0.68 mmol). The reaction mixture was stirred at 20 C under N2 for 16 hours. After cooling to r.t., the mixture was diluted with H20 (10 mL) and extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2SC>4, filtered and concentrated to give the crude product. The crude product was purified by flash chromatography on silica gel (EtOAc in PE = 0 to 30%) to give the product (23.15 mg, 0.06 mmol, 17% yield) as a solid. *H NMR (CDC13, 400MHz) deltaH = 9.08 (s, 1H), 8.68 (s, 2H), 7.95 – 7.90 (d, 2H), 7.48 (s, 2H), 7.34 (d, 2H), 4.30 (t, 2H), 3.26 (t, 2H). LCMS Rt = 1.24 min in 2.0 min chromatography, MS ESI calcd. for C19H14F3N4O3 [M+H]+ 403.1, found 402.8.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 875251-47-1, 2-(Pyrimidin-5-yl)ethanol.
Reference:
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia