Electric Literature of 89392-03-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89392-03-0, name is Phenyl (4,6-dimethoxypyrimidin-2-yl)carbamate, molecular formula is C13H13N3O4, molecular weight is 275.26, as common compound, the synthetic route is as follows.
As shown in the above reaction scheme, 6-ethyl-2-methylimidazo[1,2-b]pyridazin-3-sulfonamide (0.60 g, 2.50 mmol) and phenyl N-(4,6-dimethoxypyrimidin-2-yl)carbamate (0.76 g, 2.76 mmol) were suspended in acetonitrile (10 ml) and stirred under ice-cooling, during which DBU (0.46 g, 3.02 mmol) was added thereto. The temperature of the reaction solution was increased to room temperature, and the mixture was stirred at the same temperature for 4 hours. The reaction solution was poured into ice-water (150 ml) and adjusted to pH 3 with conc. hydrochloric acid. The reaction mixture was stirred at room temperature for 5 minutes, and the precipitated crystals were washed with water, acetonitrile and diethyl ether in this order, and collected by filtration. The crystals were dried under reduced pressure to give the title compound as colorless crystals. The yield was 0.55 g (52%), and the melting point was 172 to 174C.1H NMR(DMSO-d6, deltappm):1.02(3H, t, J=7.5Hz), 2.64(3H, s), 2.69(2H, q, J=7.5Hz), 3.97(6H, s), 6.03(1H, s), 7.44(1H, d, J=9.4Hz), 8.15(1H, d, J=9.4Hz), 10.56(1H, s), 13.21(1H, brs).
The chemical industry reduces the impact on the environment during synthesis 89392-03-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sumitomo Chemical Takeda Agro Company, Limited; EP1466527; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia