In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98138-75-1, name is 6-Chloro-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H5ClN4O
Step 2: To a solution of 6-chl oro-4-m ethoxy- li7-pyrazolo[3,4- (1227) 1.7 g, 9.2 mmol) in DMF (20 mL) was added NaH (552.6 mg, 13.8 mmol, 60% in mineral oil). After 10 min, SEM-C1 (2.3 g, 13.8 mmol, 2.5 mL) was added. The reaction mixture was stirred at 25 C for 1 hour under an atmosphere of nitrogen. The reaction mixture was concentrated under reduced pressure. The residue was diluted with water (30 mL) and extracted with EtOAc (2 x 30 mL). The combined organic layers were washed with water (2 x 30 mL), dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure to give a residue, which was purified by column chromatography (5-20% EtO Ac/petroleum ether). The desired 6-chl oro-4-methoxy-l -((2-(tri methyl si lyl)ethoxy)methyl)- l H- pyrazolo[3,4-i/]pyrimidine (1.3 g, 45.0% yield) was obtained as a light pink solid along with major impurity 6-chl oro-4-methoxy-2-((2-(tri methyl si lyl)ethoxy)methyl)-2//-pyrazolo[3, 4- i/]pyrimidine (520.0 mg, 17.9% yield), which was obtained as a light yellow solid.
The synthetic route of 98138-75-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; WALTERS, W., Patrick; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; TAYLOR, Alexander, M.; PIERCE, Levi Charles, Thomas; MURCKO, Mark, Andrew; GIORDANETTO, Fabrizio; GREISMAN, Jack, Benjamin; MARAGAKIS, Paul; BHAT, Sathesh; KONZE, Kyle; DAHLGREN, Markus, Kristofer; THERRIEN, Eric; (0 pag.)WO2019/165073; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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