Application of 4316-97-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine, molecular formula is C5H4Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Description 95; 6-Chloro-5-methyl-N- [4-trifluoromethvlphenyl] pyrimidin-4- amine; A mixture of 4, 6-dichloro-5-methylpyrimidine (1.0 g, 6.15 mmol) and 4- aminobenzotrifluoride (0.77 ml, 6.15 mmol) in ethanol (12 ml) was heated at 150C for 15 min in a microwave reactor (Personal Chemistry-Emrys Optimizer). The solid which had formed was removed by filtration and dried to give the title compound (950 mg, 53%). 1H NMR (400 MHz, CDCl3) 2.36 (3 H, s), 6.70 (2 H, br s), 7.61 (2 H, d, J8.6), 7.73 (2 H, d, J8.6), 8.44 (1 H, s).
According to the analysis of related databases, 4316-97-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia