Electric Literature of 58536-46-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, molecular weight is 387.27, as common compound, the synthetic route is as follows.
General procedure: Intermediate 8 (2.9g, 10.0 mmol), Intermediate 2 (3.9g, 10.0 mmol), Pd(PPH3)4 (0.21g, 0.2 mmol), toluene (30 mL) and a 2M aqueous solution of potassium hydroxide (15 mL) were mixed under an argon atmosphere. The mixture was stirred at 80C for 7 hours. Water was added to the reaction solution to precipitate solid matters. The solid matters were washed with methanol. The solid matters obtained were filtrated and washed with heated toluene, and then dried to obtain 3.8 g of pale yellow powder. The pale yellow powder was identified as Aromatic amine derivative (H1) by FD-MS analysis.
Statistics shows that 58536-46-2 is playing an increasingly important role. we look forward to future research findings about 4-(4-Bromophenyl)-2,6-diphenylpyrimidine.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; KATO, Tomoki; ITO, Mitsunori; INOUE, Tetsuya; OGIWARA, Toshinari; HIBINO, Kumiko; EP2589596; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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