Synthetic Route of 51940-63-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.51940-63-7, name is Ethyl 6-chloropyrimidine-4-carboxylate, molecular formula is C7H7ClN2O2, molecular weight is 186.5957, as common compound, the synthetic route is as follows.
C) (6-chloropyrimidin-4-yl)methanol To a solution of ethyl 6-chloropyrimidine-4-carboxylate (entire amount) obtained in Example 29, step B, in methanol (210 mL) was added sodium tetrahydroborate (9.99 g) at 0C, and the mixture was stirred for 30 min. To the reaction mixture was added 1N hydrochloric acid at 0C, and the mixture was extracted with a mixed solvent of ethyl acetate and THF. The solvent of the aqueous phase was evaporated under reduced pressure, and combined with the extract. The mixture was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a crude product of the title compound as a brown oil. This compound was used for the next step without further purification. 1H NMR (400 MHz, DMSO-d6) delta 4.59 (2H, d, J = 5.6 Hz), 5.76 (1H, t, J = 5.8 Hz), 7.64 (1H, s), 8.95 (1H, s).
The chemical industry reduces the impact on the environment during synthesis 51940-63-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Takeda Pharmaceutical Company Limited; MIWATASHI, Seiji; SUZUKI, Hideo; OKAWA, Tomohiro; MIYAMOTO, Yasufumi; YAMASAKI, Takeshi; HITOMI, Yuko; HIRATA, Yasuhiro; SHIBUYA, Akito; EP2816023; (2014); A1;,
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