Electric Literature of 3177-20-6, Adding some certain compound to certain chemical reactions, such as: 3177-20-6, name is Methyl 2,4-dichloropyrimidine-5-carboxylate,molecular formula is C6H4Cl2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3177-20-6.
Methyl 2-chloTo-4-{i2-(2-hYdroxyethoxy)ethyl amino}pyrimidine-5-carboxylate (1254) (1255) A solution of methyl 2,4-dichloropyrimidine-5-carboxylate (252 mg, 1.22 mmol) in i- PrOH (6 mL) was added 2-(2-aminoethoxy)ethanol (122 iL, 1.22 mmol) and DIEA (319 mu,, 1.83 mmol) at 0 °C. After 1.5 h the volatiles were removed under a reduced pressure and the residue was purified by ISCO silica gel column to provide the title compound (243 mg, 72 percent) as a white solid. 1H N R (400 MHz, CDCI3) delta 8.67 (s, 1H), 3.90 (s, 3H), 3.82-3.74 (m, 4H), 3.70 (t, J = 5.2 Hz, 2H), 3.67-3.61 (m, 2H), 2.17 (t, J = 6.3 Hz, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3177-20-6, Methyl 2,4-dichloropyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; WANG, Xiaodong; ZHANG, Weihe; FRYE, Stephen; WO2015/157127; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
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