Application of 34253-03-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34253-03-7, name is Methyl pyrimidine-2-carboxylate, molecular formula is C6H6N2O2, molecular weight is 138.12, as common compound, the synthetic route is as follows.
1-(3-Benzylphenyl)-3-pyrimidin-2-yl-propane-1,3-dione (5R). To a solution of 4B (0.3 g, 1.43 mmol) and methyl pyrimidine-2-carboxylate (0.197 g, 1.43 mmol) in THF (7.0 ml) was added sodium methoxide (0.154 g, 2.85 mmol). After one hour of stirring at room temperature the yellow solution was poured into a saturated solution of ammonium chloride, extracted with ethyl acetate, dried over sodium sulfate, filtered and concentrated to give a yellow oil. The oil was dissolved in DMSO and purified using reverse phase HPLC on a C18 column to give a light colored solid, (5R) after lyophilization. 1H NMR (400 MHz, CDCl3) delta 8.97-8.96 (d, j=4.8 Hz, 2 H), 7.94-7.91 (m, 2 H), 7.61 (s, 1 H), 7.46-7.39 (m, 3 H), 7.32-7.19 (m, 5 H), 4.07 (s,2 H).
The chemical industry reduces the impact on the environment during synthesis 34253-03-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
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