Adding a certain compound to certain chemical reactions, such as: 1195768-23-0, N-(3-(2-(tert-Butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1195768-23-0, blongs to pyrimidines compound. SDS of cas: 1195768-23-0
A suspension of N-(3-(2-(tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2- fluorophenyl)-2,6-difluorobenzenesulfonamide (50.0mg, 0.092mmol) and aniline (9.0mg, 0.097mmol) in iPrOH (lmL), in presence of catalytic concentrated HC1, was stirred at 100C for lh, then at 80C overnight. The mixture was concentrated under reduced pressure. The residue was partitioned between EtOAc and saturated aqueous sodium bicarbonate. The organic layer was washed with brine, dried over sodium sulphate, filtered and the filtrate was concentrated under vacuum. Purification by flash chromatography on silica gel (cHex-EtOAc, 1/0 to 0/1) afforded the title compound 1 (40mg, 72%). lU NMR (CDC13): 8.09 (d, 1H, J = 5.2 Hz); 7.84 (bs, 1H); 7.72 (m, 1H); 7.48 (d, 2H, J = 7.7Hz); 7.44-7.36 (m, 3H); 7.29 (t, 2H, J = 7.5Hz); 7.24 (t, 1H, J = 7.3Hz); 7.02 (t, 1H, J = 7.7Hz); 6.92 (t, 2H, J = 8.7Hz); 6.28 (d, 1H, J = 5.2Hz); 1.48 (s, 9H). LC/MS (ES+): 596.2 (M+l).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1195768-23-0, its application will become more common.
Reference:
Patent; CELLIPSE; PRUDENT, Renaud; PAUBLANT, Fabrice; (74 pag.)WO2018/55097; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia