Reference of 18592-13-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18592-13-7, name is 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: The respective halomethyl derivatives {6-(chloromethyl)uracil (0.1150g, 0.716mmol) or 4-bromomethyl-7-methoxycoumarin (0.1928g, 0.716mmol)} were suspended in acetone (1.5cm3) and then added individually to alkaline mixtures comprised of NaOH (0.0286g, 0.716mmol) in distilled water (1cm3). Upon dissolution of the organic precursors, the corresponding solutions were introduce in a dropwise manner to particular reaction mixtures of di(2-picolyl)amine (0.1001g, 0.5024mmol) and K2CO3 (0.069g, 0.5018mmol) in acetone (4.0cm3). Thereafter, the resultant reaction mixtures were heated at reflux for 24h, which was followed by the reduction of the solvent under vacuum. The respective residues were dispersed in separate 1:1 (v:v) water and chloroform combinations. Then the crude individual oily products were attained by the triplicate extractions from the aqueous mixture using chloroform and these extracts were dried over anhydrous MgSO4 prior to removing the solvent under reduced pressure. The relating crude products were purified by column chromatography using a silica stationary phase and DCM: MeOH (v:v, 9:1) as a mobile phase. 2.2.2 6-((bis(pyridin-2-ylmethyl)amino)methyl)uracil (Hurdpa) X-ray quality single crystals were grown via the slow diffusion of n-hexane into a solution of dichloromethane. Yield: 0.72g (51%). Molecular mass (m/z): Cald. for C17H17N5O2: 323.14. Found: 346.13 [M+Na]+ (Fig. S3). FTIR (cm-1): v(N-H) 3370 (br, w); v(C=O) 1681 (vs); v(C=N) 1579 (s); v(C-N) 1161, 1136 (m). 1H NMR (d6-DMSO/ppm/298K, Fig. S4): 11.04 (br, s, 1H, N5H); 10.87 (s, 1H, N4H); 8.55-8.50 (m, 2H, H1, H12); 7.84-7.75 (m, 2H, H3, H10); 7.52-7.46 (m, 2H, H2, H11); 7.33-7.24 (m, 2H, H4, H9); 5.57 (s, 1H, H17); 3.90-3.83 (m, 4H, H6, H6?, H7, H7?); 3.52 (br, s, 2H, H13, H13?). UV-Vis (MeOH, lambdamax (epsilon, M-1cm-1)): 256nm (sh, 1540); 262nm (1720); 268nm (sh, 1350); 359nm (10)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18592-13-7, 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione.
Reference:
Article; Gramni, Larusha; Vukea, Nyeleti; Chakraborty, Abir; Samson, William John; Dingle, Laura Margaret Kirkpartick; Xulu, Bheki; de la Mare, Jo-Anne; Edkins, Adrienne Lesley; Booysen, Irvin Noel; Inorganica Chimica Acta; vol. 492; (2019); p. 98 – 107;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia