Synthetic Route of 14080-23-0 ,Some common heterocyclic compound, 14080-23-0, molecular formula is C5H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Pyrimidine-2-carboxylic acid (11):To a stirred solution of pyrimidine-2-carbonitrile (10) (201 mg, 1.914 mmol) in water (5 mL), KOH (214.3 mg, 3.83 mmol) was added and the reaction was refluxed for 3 h. After consumption of the starting material (by TLC), the reaction was slowly brought to RT, neutralized with 2N HC1 and water was removed from the reaction mixture to give the crude residue which was extracted with EtOAc. The combined organic extracts were filtered through a pad of celite and the filtrate was concentrated under reduced pressure to provide compound 11 (84 mg, 35.4%) which was carried for the next step without any purification.TLC: 80% EtOAc/Hexane (Rf: 0.05)1H NMR (400MHz, CD3OD-d4): delta 8.83 (br s, 2H), 7.47 (t, J = 4.8 Hz, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14080-23-0, its application will become more common.
Reference:
Patent; THERACRINE, INC.; SUN, Lijun; BARSOUM, James; WESTER, Ronald; WO2013/13238; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia