Synthetic Route of 16357-69-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16357-69-0, name is 4-Aminopyrimidine-5-carbonitrile, molecular formula is C5H4N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-Aminopyrimidine-5-carbonitrile (0.945 g, 7.87 mmol) was suspended in water (9.50 mL) and mixture was chilled briefly. Sulfuric acid (1.90 mL) was added. Solid went into solution, resulting in a clear yellow solution. Palladium on carbon (10%; 143 mg, 134 mumol) was added and solution was hydrogenated (RT; 18-30 psi) for 90 minutes. The mixture was filtered through a bed of Celite to remove the catalyst. The clear, pale yellow filtrate was treated with concentrated ammonium hydroxide to neutralize the acid. After chilling, the solid was collected, washed with cold water and air-dried with suction under house vacuum to give 4-amino-pyrimidine-5-carbaldehyde. (Yield 0.654 g, 5.31 mmol, 67.5%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16357-69-0, 4-Aminopyrimidine-5-carbonitrile.
Reference:
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia