The origin of a common compound about Synthetic Route of 18740-39-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18740-39-1, 2,4-Dichlorothieno[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Synthetic Route of 18740-39-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18740-39-1, name is 2,4-Dichlorothieno[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

Weigh 11-a (125 mg, 1 eq) and methyl p-aminobenzoate (67 mg, 1.2 eq). Butanol was added to dissolve, then p-toluenesulfonic acid (7 mg, 0.1 eq) was added, and the reaction was carried out at 170¡ã C. for 2 hours in the microwave. Cool and filter to obtain crude compound 12-a crude (168 mg, 99percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18740-39-1, 2,4-Dichlorothieno[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Xin Minxing; Tang Feng; Wen Jun; Shen Han; Tu Chongxing; Zhao Xinge; (48 pag.)CN104177363; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia