In 2018,Tian, Chao; Han, Zifei; Li, Yuanxin; Wang, Meng; Yang, Jiajia; Wang, Xiaowei; Zhang, Zhili; Liu, Junyi published 《Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstituted-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d]pyrimidine analogues as novel CHK1 inhibitors》.European Journal of Medicinal Chemistry published the findings.Recommanded Product: 90213-66-4 The information in the text is summarized as follows:
Arylamino imidazopyrimidines, thienopyrimidines, and pyrrolopyrimidines such as I were prepared as inhibitors of checkpoint kinase 1 (CHK1) for potential use as antitumor agents. I exhibited low anti-proliferative effects towards HT29 and Hek293 cell lines, potentiated the antitumor activity of gemcitabine in HT29 cells, and was selective for CHK1 over a panel of fourteen other kinases. I induced S phase accumulation in gemcitabine-treated HT29 cells. After reading the article, we found that the author used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Recommanded Product: 90213-66-4)
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: 90213-66-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia