Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core was written by Tice, Colin M.;Noto, Paul B.;Fan, Kristi Yi;Zhao, Wei;Lotesta, Stephen D.;Dong, Chengguo;Marcus, Andrew P.;Zheng, Ya-Jun;Chen, Guozhou;Wu, Zhongren;Van Orden, Rebecca;Zhou, Jing;Bukhtiyarov, Yuri;Zhao, Yi;Lipinski, Kerri;Howard, Lamont;Guo, Joan;Kandpal, Geeta;Meng, Shi;Hardy, Andrew;Krosky, Paula;Gregg, Richard E.;Leftheris, Katerina;McKeever, Brian M.;Singh, Suresh B.;Lala, Deepak;McGeehan, Gerard M.;Zhuang, Linghang;Claremon, David A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Quality Control of Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate This article mentions the following:
Liver X receptor (LXR) agonists have been reported to lower brain amyloid beta (Aβ) and thus to have potential for the treatment of Alzheimer’s disease. Structure and property based design led to the discovery of a series of orally bioavailable, brain penetrant LXR agonists. Oral administration of compound 18 to rats resulted in significant upregulation of the expression of the LXR target gene ABCA1 in brain tissue, but no significant effect on Aβ levels was detected. In the experiment, the researchers used many compounds, for example, Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6Quality Control of Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate).
Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Quality Control of Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia