The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 109-12-6.
Titi, Abderrahim;Touzani, Rachid;Moliterni, Anna;Hadda, Taibi Ben;Messali, Mouslim;Benabbes, Redouanae;Berredjem, Malika;Bouzina, Abdeslem;Al-Zaqri, Nabil;Taleb, Mustapha;Zarrouk, Abdelkader;Warad, Ismail research published 《 Synthesis, structural, biocomputational modeling and antifungal activity of novel armed pyrazoles》, the research content is summarized as follows. Nowadays, facile and short synthesis of new antifungal pyrazole-derivatives ligands has attracted increasing attention due to their simplicity and effectiveness. In here, a new family of pyrazole in one step by condensation of [NNOH:(1H-pyrazol-1-yl)methanol], [NCOH:(3,5-dimethyl-1H-pyrazol-1-yl)methanol], and [NOCOH:ethyl1-(hydroxymethyl)-5-methyl-1H-pyrazole-3carboxylate] with several amines ligands was prepared All structures of I = II = III = IV = V = [R1 = H, CH3; R2 = H, CH3, CO2Et, etc.], were structured by spectroscopies methods, particularly FTIR, 1H-NMR, 13C-NMR, plus (EA%)-elemental anal., as well as, the evaluation of its antifungal properties against Fusarium Oxysporum Albedinis (FOA). The important substantial results were obtained for the compounds I [R1 = R2 = H], II [R1 = R2 = H], II [R1 = R2 = CH3] and IV [R1 = R2 = H] with MIC50 78-92μg/mL. Bioinformatics calculations (POM and DFT/Docking analyses) were used to predict and optimize these antifungal results. Both exptl. and theor. results showed a good agreement.
Quality Control of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia