Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 2927-71-1, Name is 2,4-Dichloro-5-fluoropyrimidine, SMILES is C1=C(C(=NC(=N1)Cl)Cl)F, in an article , author is Shariev, Artur, once mentioned of 2927-71-1, SDS of cas: 2927-71-1.
Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic
Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper (Cu2+ -Cu3+)-centred polyglycine coordination complex. It displays 10-fold higher superoxide quenching activity compared to SOD as well as significant antioxidant, anti-inflammatory and immunomodulatory activities through beneficial modulation of several significant inflammatory cytokines in vitro and in vivo. We tested the therapeutic potential of RM191A in a topical gel using a human skin explant model and observed that it significantly inhibits UV-induced DNA damage in the epidermis and dermis, including cyclobutane pyrimidine dimers (CPD), 8-oxo-guanine (8-oxoG) and 8-nitroguanine (8NGO). RM191A topical gel is found to be non-toxic, non-teratogenic and readily distributed in the body of mice. Moreover, it significantly accelerates excisional wound healing, reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation and attenuates age-associated oxidative stress in skin, demonstrating both skin regenerative and geroprotective properties of RM191A.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2927-71-1, you can contact me at any time and look forward to more communication. SDS of cas: 2927-71-1.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia