HPLC of Formula: 122567-97-9On March 31, 1994, Tortolani, David R.; Russell, John W.; Whiterock, Valerie J.; Hitchcock, Michael J. M.; Ghazzouli, Ismail; Martin, John C.; Mansuri, Muzammil M.; Starrett, John E. Jr. published an article in Journal of Pharmaceutical Sciences. The article was 《Prodrugs of 2′,3′-Didehydro-3′-deoxythymidine (D4T): Synthesis, Antiviral Activity, and Rapid Pharmacokinetic Evaluation》. The article mentions the following:
A series of 5′-derivatives and modified pyrimidine analogs of 2′,3′-didehydro-3′-deoxythymidine (d4T, stavudine) were synthesized to determine their potential as oral prodrugs of d4T. Utilizing a screen developed for the rapid evaluation of a variety of prodrugs in mice, it was determined that 5′-acetate provided comparable plasma levels of d4T after oral administration of the prodrug to that when d4T was administered alone. The relative oral bioavailability of methoxy acetate and cyclohexyl carbonate derivatives was 79 and 41%, resp. The dihydropyridine ester did not provide detectable levels of d4T up to 1 h after oral administration of 6. Thiopyrimidine and aminopyrimidine derivatives also failed to provide measurable levels of d4T after oral administration. 5′-Derivatives showed similar activity to that of d4T against HIV and MuLV, as did 5′-benzoyl-4-thio derivative However, the corresponding 4-thio 5′-alc. derivative was inactive. In the experimental materials used by the author, we found ((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9HPLC of Formula: 122567-97-9)
((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.HPLC of Formula: 122567-97-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia