The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Application In Synthesis of 4595-59-9.
Tran, Ryan Q.;Dinh, Long P.;Jacoby, Seth A.;Harris, Nekoda W.;Swann, William A.;Williamson, Savannah N.;Semsey, Rebecca Y.;Yet, Larry research published 《 Synthesis of 3-aryl-1-phosphinoimidazo[1,5-a]pyridine ligands for use in Suzuki-Miyaura cross-coupling reactions》, the research content is summarized as follows. 3-Aryl-1-phosphinoimidazo[1,5-a]pyridine ligands I [R = Cy, Ph; Ar = Ph, 2-MeOC6H4, 2,6-(OMe)2C6H3, etc.] were synthesized from 2-aminomethylpyridine as the initial substrate via two complementary routes. The first synthetic pathway underwent the coupling of 2-aminomethylpyridine with substituted benzoyl chlorides, followed by cyclization, iodination and palladium-catalyzed cross-coupling phosphination reactions sequence to give phosphorus ligands I. In the second route, 2-aminomethylpyridine was cyclized with aryl aldehydes, followed by the iodination and palladium-catalyzed cross-coupling phosphination reactions to yield phosphorus ligands I. Ligands I were evaluated in synthesis of sterically-hindered biaryls and heterobiaryls R1-R2 [R = 2-H2N6H4, 4-NC6H4, 3-pyridyl, etc.; R1 = 2-MeO6H4, 3-thienyl, 3-pyridyl, etc.] via palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of hetero(aryl) halides with hetero(aryl)boronic acids.
4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Application In Synthesis of 4595-59-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia