Tseng, Chih-Hua published the artcileSynthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers, Category: pyrimidines, the main research area is methoxyphenylquinolinyl aryl propenone stereoselective preparation antitumor activity; structure methoxyphenylquinolinyl aryl propenone inhibition human cancer normal cell; breast non small cell lung cancer inhibition methoxyphenylquinolinyl arylpropenone; cell cycle progression cellular administration methoxyphenylquinolinyl aryl propenone; cleavage apoptotic protein cellular administration methoxyphenylquinolinyl aryl propenone; methoxyphenyl methoxyphenylquinolinyl propenone mol crystal structure.
3-(4-Methoxyphenyl)quinolinyl aryl propenones I [R = Ph, 4-FC6H4, 4-HOC6H4, 4-MeOC6H4, 2,4-(MeO)2C6H3, 2,6-(MeO)2C6H3, 3,4-(MeO)2C6H3, 3,5-(MeO)2C6H3, 4-H2NC6H4, 4-O2NC6H4, 2-furyl, 2-thienyl, 2-pyridinyl, 5-Br-2-thienyl, 3-thienyl, 2-pyrrolyl, 3-amino-2-thienyl, 2-amino-4-methyl-5-pyrimidinyl, 3-indolyl] were prepared as potential antitumor agents. I (R = Ph) inhibited the growth of H1299 non-small cell lung cancer and SKBR-3 breast cancer cells with IC50 values of 1.41 and 0.70 μM, resp., while the standard topotecan inhibited their growth with IC50 values of 6.02 and 8.91 μM, resp. I (R = 5-Br-2-thienyl) inhibited the growth of MDA-MB-231 breast cancer cells with an IC50 value of less than 0.10 μM, while inhibiting the growth of noncancerous mammary epithelial cells at an IC50 value of 9.38 μM. I (R = 5-Br-2-thienyl) induced cell cycle arrest at G2/M phase followed by activation of caspase-3, cleavage of PARP, and cell death. The structure of I [R = 2,4-(MeO)2C6H3] was determined by X-ray crystallog.
European Journal of Medicinal Chemistry published new progress about Antitumor agents. 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, Category: pyrimidines.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia