Application of 3934-20-1In 2022 ,《Strain-Release-Driven Friedel-Crafts Spirocyclization of Azabicyclo[1.1.0]butanes》 was published in Angewandte Chemie, International Edition. The article was written by Tyler, Jasper L.; Noble, Adam; Aggarwal, Varinder K.. The article contains the following contents:
The strain-release-driven Friedel-Crafts spirocyclization of azabicyclo[1.1.0]butane-tethered (hetero)aryls I (R = H, Me, Bn, allyl, triethylsilyl; R1 = Ph, 2-naphthyl, benzothiophen-2-yl, etc.) for the synthesis of a unique library of azetidine spiro-tetralins e.g., II was reported. The reaction was discovered to proceed through an unexpected interrupted Friedel-Crafts mechanism, generating a highly complex azabicyclo[2.1.1]hexane scaffold. This dearomatized intermediate, formed exclusively as a single diastereomer, can be subsequently converted to the Friedel-Crafts product upon electrophilic activation of the tertiary amine, or trapped as a Diels-Alder adduct in one-pot. The rapid assembly of mol. complexity demonstrated in these reactions highlights the potential of the strain-release-driven spirocyclization strategy to be utilized in the synthesis of medicinally relevant scaffolds. The experimental process involved the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Application of 3934-20-1)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 3934-20-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia