Tzeng, Cherng-Chyi; Hwang, Long-Chih; Chen, Chien-Chi; Wei, Dau-Chang published the artcile< Synthesis of racemic 5-substituted 1-(2,3-dihydroxypropyl)-6-azauracils and their isosteric isomers>, Application In Synthesis of 4956-05-2, the main research area is azauracil acyclic nucleoside synthesis antiviral; hydroxypropylazauracil synthesis antiviral.
Acyclic nucleoside analogs of antiviral DHPA and HPMPA have been prepared Coupling of silylated 6-azauracils with benzyl glycidyl ether and stannic chloride followed by the deprotection with boron trichloride gave 1-(2,3-dihydroxypropyl)-6-azauracils in good overall yields. Reaction of silylated 6-azauracil and epichlorohydrin with or without catalytic stannic chloride afforded 1-(2-chloro-3-hydroxypropyl)-6-azauracil and 1-(3-chloro-2-hydroxypropyl)-6-azauracil resp. Coupling of silylated 6-azaisocytosine under the same reaction conditions provided 1-(2,3-dihydroxypropyl)-6-azaisocytosine and 1-(2-chloro-3-hydroxypropyl)-6-azaisocytosine. None of the compounds exhibited significant antiviral activity against herpes simplex viruses.
Nucleosides & Nucleotides published new progress about Acyclonucleosides Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Application In Synthesis of 4956-05-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia