On March 5, 2020, Umesaki, Keisho; Odai, Kei published an article.Category: pyrimidines The title of the article was A Kinetic Approach to Double Proton Transfer in Watson-Crick DNA Base Pairs. And the article contained the following:
Double proton transfer (DPT) in guanine-cytosine (GC) base pairs and adenine-thymine (AT) base pairs produces tautomeric forms, denoted G*C* and A*T*. To examine DPT, (i) intrinsic reaction coordinates for DPT, (ii) probabilities of change from GC to G*C* and from AT to A*T*, and (iii) IR absorption intensities of GC and G*C* were investigated on the basis of d. functional theory and Eyring’s chem. kinetics. The probabilities of change from GC to G*C* were 3 × 10-8, and those from AT to A*T* were 2 × 10-10. These values are consistent with the rate of mutation previously reported by Drake et al. G*C* exhibited two vibrational modes around 3000 cm-1, whereas GC exhibited no vibrational modes around the same frequency. The IR intensity calculated for G*C* showed that the strong absorption obtained around 3000 cm-1 was caused by one of the two modes. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Category: pyrimidines
The Article related to watson crick dna base pair double proton transfer kinetics, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia