Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Application of C4H3BrN2.
Utepova, Irina A.;Nemytov, Alexey I.;Ishkhanian, Victoria A.;Chupakhin, Oleg N.;Charushin, Valery N. research published 《 Metal-free C-H/C-H coupling of 1,3-diazines and 1,2,4-triazines with 2-naphthols facilitated by Bronsted acids》, the research content is summarized as follows. One-pot protocol metal-free oxidative C-H/C-H coupling of azines with 2-naphthols facilitated by a Bronsted acid has been developed. The method affords the corresponding azinylnaphthols, a basic scaffold of atropisomeric catalysts for asym. synthesis and fluorophores. The advantages of the proposed protocol include mild reaction conditions, high regio- and chemoselectivity and scalability.
4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Application of C4H3BrN2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia