Alterations in the recognition of nucleoside analogs as substrates by the deoxythymidine kinase of a 5-methoxymethyldeoxyuridine-resistant mutant of herpes simplex virus type 1 was written by Veerisetty, V.; Veerisetty, Indira K.; Gentry, Glenn A.. And the article was included in Journal of General Virology on December 31,1983.HPLC of Formula: 69256-17-3 The following contents are mentioned in the article:
Inhibition constants (Kis) were used as an estimate of the ability of various nucleoside analogs to be recognized as substrates by the deoxythymidine kinases (dTKs) of a 5-methoxymethyldeoxyuridine-resistant (MMdUr) mutant of herpes simplex virus type 1 (HSV-1) and its parent wild-type (wt). The Kis for the 5-position analogs MMdU, [E]-5-(2-bromovinyl)deoxyuridine, bromodeoxyuridine, and iododeoxyuridine were increased approx. 3-5-fold, suggesting that they were poorer substrates for the MMdUr dTK than for the wt dTK. With the 2′ analogs arabinosylthymine and 2′-fluoro-5-methylarabinosyluracil, however, the Kis were increased to a much greater extent, 80- and 240-fold, resp. These findings suggest that the resistance of the mutant MMdUr to these analogs may be due to a mutation(s) in the viral dTK that directly affects binding at the 2′ recognition site and indirectly at the 5, while still allowing substantial activity with the natural substrate deoxythymidine. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3HPLC of Formula: 69256-17-3).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 69256-17-3
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3