Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway was written by Vrijens, Pieter;Noppen, Sam;Boogaerts, Talitha;Vanstreels, Els;Ronca, Roberto;Chiodelli, Paola;Laporte, Manon;Vanderlinden, Evelien;Liekens, Sandra;Stevaert, Annelies;Naesens, Lieve. And the article was included in Journal of General Virology in 2019.COA of Formula: C28H41N7O3 The following contents are mentioned in the article:
This requires a better understanding of virus- host interactions during the entry process, including the role of receptor tyrosine kinases (RTKs). To search for cellular targets, we evaluated a panel of 276 protein kinase inhibitors in a multicycle antiviral assay in Madin-Darby canine kidney cells. The RTK inhibitor Ki8751 displayed robust anti-influenza A and B virus activity and was selected for mechanistic investigations. Ki8751 efficiently disrupted the endocytic process of influenza virus in different cell lines carrying plateletderived growth factor receptor β (PDGFRb), an RTK that is known to act at GM3 ganglioside-pos. lipid rafts. The more efficient virus entry in CHO-K1 cells compared to the wild-type ancestor (CHO-wt) cells indicated a pos. effect of GM3, which is abundant in CHO-K1 but not in CHO-wt cells. Entering virus localized to GM3-pos. lipid rafts and the PDGFRbcontaining endosomal compartment. PDGFRβ/GM3-dependent virus internalization involved PDGFRβ phosphorylation, which was potently inhibited by Ki8751, and desialylation of activated PDGFRb by the viral neuraminidase. Virus uptake coincided with strong activation of the Raf/MEK/Erk cascade, but not of PI3K/Akt or phospholipase C-γ. We conclude that influenza virus efficiently hijacks the GM3-enhanced PDGFR β signaling pathway for cell penetration, providing an opportunity for host cell-targeting antiviral intervention. This study involved multiple reactions and reactants, such as 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7COA of Formula: C28H41N7O3).
1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.COA of Formula: C28H41N7O3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia