Wakitani, Shoichi et al. published their research in Biochimica et Biophysica Acta, Molecular Cell Research in 2022 | CAS: 219580-11-7

1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C28H41N7O3

The FGF receptor inhibitor PD173074 modulates Lefty expression in human induced pluripotent stem cells differently depending on the culture conditions was written by Wakitani, Shoichi. And the article was included in Biochimica et Biophysica Acta, Molecular Cell Research in 2022.Synthetic Route of C28H41N7O3 The following contents are mentioned in the article:

Pluripotent stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are infinitely proliferative cells that have the ability to differentiate into somatic lineage cells. Nodal activates type 1 and 2 activin receptors to regulate transcription via phosphorylation of Smad2/3. In the present study, to elucidate the detailed mechanism of the synergistic action of FGF and the Nodal-Cripto pathway, the initial response of gene expression in human iPSCs to the FGF receptor inhibitor PD173074 (PD) was investigated, focusing on genes that block the Nodal-Cripto pathway. The confusing alterations in NODAL and LEFTY1/2 expression, which were induced by PD treatment and depended on culture conditions, can be explained by two different functions of CRIPTO, both as a Nodal co-receptor and an activin antagonist. In conclusion, the present study revealed that inhibition of FGF signaling in human iPSCs acutely affected the expression of Nodal/ Activin target genes in an opposing manner, depending on the presence of feeder cells. This study involved multiple reactions and reactants, such as 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7Synthetic Route of C28H41N7O3).

1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C28H41N7O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia