《General dual functionalisation of biomacromolecules via a cysteine bridging strategy》 was written by Walsh, Stephen J.; Iegre, Jessica; Seki, Hikaru; Bargh, Jonathan D.; Sore, Hannah F.; Parker, Jeremy S.; Carroll, Jason S.; Spring, David R.. COA of Formula: C4HCl3N2 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:
Site-selective modification of peptides and proteins resulted in the development of a host of novel tools for the study of cellular systems or the synthesis of enhanced biotherapeutics. There is a need for useful methodologies that enable site-selective modification of native peptides or proteins, which is even more prevalent when modification of the biomol. with multiple payloads is desired. Herein, the authors report the development of a novel dual functional divinylpyrimidine (dfDVP) platform that enables robust and modular modification of peptides, antibody fragments and antibodies. These biomacromols. could be easily functionalized with a range of functional payloads (e.g. fluorescent dyes, cytotoxic warheads or cell-penetrating tags). Importantly, the dual functionalized peptides and antibodies demonstrated exquisite bioactivity in a range of in vitro cellular assays, showcasing the enhanced utility of these bioactive conjugates. In the experiment, the researchers used many compounds, for example, 2,4,6-Trichloropyrimidine(cas: 3764-01-0COA of Formula: C4HCl3N2)
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.COA of Formula: C4HCl3N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia