On January 23, 2013, Wang, Lei published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Preparation method of compound oral liquid of neomycin sulfate and its application in treating severe diarrhea of poultry. And the patent contained the following:
The title compound oral liquid comprises neomycin sulfate 8-15, berberine hydrochloride 3-6, trimethoprim lactate 1-3, astragalan for injection 10-20, levamisole hydrochloride 2-4, acetaminophen 5-15 and water for injection 60-80 weight parts. The preparation method consists of adding 2/3 water for injection (60-70°C), adding remaining materials in sequential order, stirring, adding remaining water for injection, filling with nitrogen gas, adding 0.05-0.2% active carbon, decoloring for 20-30 min, filtering off carbon, detecting content and pH value, filtering at 0.45 or 0.6 um, bottling, and sterilizing with 100°C steam for 30 min. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to compound oral liquid neomycin sulfate severe diarrhea poultry, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia