On October 11, 2006, Wang, Lianmin; Zhang, Xinglong; Hua, Yunfang published a patent.Category: pyrimidines The title of the patent was Manufacture of veterinary amikacin sulfate compound injection containing trimethoprim. And the patent contained the following:
The title injection is manufactured by: (1) dissolving trimethoprim lactate into injection water, and adding propanediol, (2) dissolving sodium metabisulfite into injection water, (3) dissolving amikacin sulfate in injection water, and (4) mixing solutions obtained from step 1, 2, and 3, adjusting pH to 4.0-5.0, prefiltering, microfiltering, and sterilizing to obtain the final product. This injection can be used to synthesize abnormal proteins from bacteria to inhibit proteins from releasing, and enlarge cell membrane permeability of bacteria to inhibit proliferation of bacteria. This injection has reinforced antibacterial effect through synergistic effect of trimethoprim and amikacin sulfate. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Category: pyrimidines
The Article related to veterinary amikacin sulfate injection trimethoprim, Pharmaceuticals: Formulation and Compounding and other aspects.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia