On October 15, 2014, Wang, Yuwan; Pan, Zhende; Peng, Xin; Guo, Qiang; Dai, Xiaoxi; Ren, Yanan; Shen, Li published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was A preparation method of tulathromycin emulsifiable injection. And the patent contained the following:
A tulathromycin emulsifiable injection (per litre) comprises tulathromycin 60-200 g, poloxamer 188 30-120 g, an antioxidant 0.3-0.6 g, and an oil medium in balance. A proper amount of hydrogenated castor oil and soybean lecithin can also be added in the injection. It is characterized in that emulsification occurs to the injection when meeting water (or fluid) to form a mixed system of emulsion droplets and oil. The injection has both quick-release and long acting effects, also has a high drug-loading amount, good stability, and good biocompatibility. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to tulathromycin emulsification injection veterinary drug poloxamer, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia