On June 10, 2015, Wang, Yuwan; Dai, Xiaoxi; Pan, Zhende; Ren, Yanan; Li, Lei; Li, Ying; Weng, Zhifei; Shen, Li published a patent.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Preparation method of emulsifiable oleaginous injection containing hydrophilic medicine. And the patent contained the following:
The title emulsifiable oleaginous injection containing hydrophilic medicine is composed of hydrophilic medicine (such as valnemulin hydrochloride, tiamulin fumarate, etc.) 80-200g, poloxamer 188 20-60g, soybean phospholipids 1-5g and injection soybean oil or soybean oil/ethyl oleate to 1L. The preparation method of the emulsifiable oleaginous injection includes sterilizing injection soybean oil by heating, cooling, adding other materials and sand milling. Emulsification of emulsifiable oleaginous injection containing hydrophilic medicine occurs, when the emulsifiable oleaginous injection contacts to water, forming a emulsion or emulsion/oil system, thus reducing the release rate of drug. The emulsifiable oleaginous injection has large drug load, good biocompatibility, good stability and easy preparation method. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to hydrophilic medicine emulsifiable oleaginous injection, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia