Nucleosides. 110. Synthesis and antiherpes virus activity of some 2′-fluoro-2′-deoxyarabinofuranosylpyrimidine nucleosides was written by Watanabe, Kyoichi A.; Reichman, Uri; Hirota, Kosaku; Lopez, Carlos; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1979.Synthetic Route of C9H12FN3O4 The following contents are mentioned in the article:
The title compounds were prepared by condensation of 3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinosyl bromide [56632-81-6] with the appropriate trimethylsilylated pyrimidines followed by saponification of the protected nucleosides, and evaluated for antiherpes virus activity. 1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] was the most effective showing 99.5% suppression of viral replication even at concentrations of 0.1 μg/mL. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Synthetic Route of C9H12FN3O4).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C9H12FN3O4
56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8