Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-β-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships was written by Watanabe, Kyoichi A.; Su, Tsann Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; Chun, Moon Woo; Lopez, Carlos; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1983.Category: pyrimidines The following contents are mentioned in the article:
Several 2′-deoxy-2′-halogenoarabinofuranosylcytosines and -uracils substituted at C-5 of the aglycon with Br or I were prepared and evaluated for antiherpetic activity against both herpes virus type 1 and 2 on monolayers of Vero cells by the plaque reduction assay. A dose that reduced the number of virus plaques by 50% (ED50) was determined The 2′-F function showed better antiviral activity than the corresponding 2′-Br or Cl congeners. 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (I) [69123-90-6] had the most potent activity in vitro. Structure-activity relations are discussed. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Category: pyrimidines).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Category: pyrimidines
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3