Watanabe, Kyoichi A. et al. published their research in Journal of Medicinal Chemistry in 1990 | CAS: 56632-83-8

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C9H12FN3O4

Synthesis and anti-HIV-1 activity of 2′-“”up””-fluoro analogs of active anti-AIDS nucleosides 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine (DDC) was written by Watanabe, Kyoichi A.; Harada, Kazuho; Zeidler, Joanna; Matulic-Adamic, Jasenka; Takahashi, Kiyobumi; Ren, Wu Yun; Cheng, Ling Chin; Fox, Jack J.; Chou, Ting Chao. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Synthetic Route of C9H12FN3O4 The following contents are mentioned in the article:

1-(3-Azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine (I) and 1-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)cytosine (II) were synthesized from the potent antiherpes virus nucleosides 1-(2-fluoro-β-D-arabinofuranosyl)thymine and 1-(2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine in the hope that introduction of a 2′-“”up””-fluoro substituent might potentiate the anti-HIV activity of 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine. I did not exhibit any significant activity against the human immunodeficiency virus (HIV) in vitro. II, however, showed activity against HIV-1, but the therapeutic index was much inferior to that of AZT. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Synthetic Route of C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8