In an article, author is Esteban-Parra, Gines M., once mentioned the application of 3993-78-0, Formula: C4H4ClN3, Name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.55, MDL number is MFCD00038021, category is pyrimidines. Now introduce a scientific discovery about this category.
Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5-alpha] pyrimidine ligand
We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1,2,4-triazolo[1,5-alpha] pyrimidine (7-amtp), and a new family of coordination compounds based on this ligand and zinc as metal ion, synthesized by conventional routes. These materials possess different mononuclear structures, namely [ZnCl2(7-amtp)(2)] (1), [Zn(7-amtp)(2)(H2O)(4)](NO3)(2)2(7-amtp)6H(2)O (2) and [Zn(7-amtp)(2)(H2O)(4)](SO4)1.5H(2)O (3) derived from the use of different zinc (II) salts, in such a way that the counterions govern the crystallization to a large extent. These compounds present and show variable luminescent properties based on ligand-centred charge transfers which have been deeply studied by Time Dependent Density Functional Theory (TD-DFT) calculations. When these compounds are transferred to solution, preserving complex entities as corroborated by NMR studies, they present interesting anti-diabetic and anti-parasitic capabilities, with a comparatively higher selectivity index than other previously reported triazolopyrimidine-based materials. The results derived from in vivo experiments conducted in mice also confirm their promising activity as anti-diabetic drug being capable of dropping glucose levels after oral administration. Therefore, these new materials may be considered as excellent candidates to be further investigated in the field of luminescent coordination compounds with biomedical applications.
If you are interested in 3993-78-0, you can contact me at any time and look forward to more communication. Formula: C4H4ClN3.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia