Synthetic Route of 36315-01-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 36315-01-2, Name is 2-Amino-4,6-dimethoxypyrimidine, SMILES is C1=C(N=C(N=C1OC)N)OC, belongs to pyrimidines compound. In a article, author is Jia, Cong-Cong, introduce new discover of the category.
Recent developments of RET protein kinase inhibitors with diverse scaffolds as hinge binders
RET is a proto-oncogene encoding a receptor tyrosine kinase. RET regulates key aspects of cellular proliferation, differentiation and survival. The activation of RET via gene fusions or point mutations is closely related to lung, thyroid and other cancers. This review summarizes the developments of a diversity of small molecule RET protein kinase inhibitors in the past 10 years. These RET inhibitors are classified according to their hinge binder chemotypes as: pyrimidines, including the pyrazolopyrimidines, pyrimidine oxazines, quinazolines, 4-aminopyrimidines and 4-aminopyridines; indolinones; 5-aminopyrazole-4-carboxamides; 3-trifluoromethylanilines; imidazopyridines, imidazopyridazines and pyrazopyridines; nicotinonitriles; pyridones and 1,2,4-triazoles. In each section, the biological activities of the inhibitors, their structure-activity relationships and possible binding modes with the RET kinase are introduced.
Synthetic Route of 36315-01-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 36315-01-2.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia