White, James D. published the artcileTotal Synthesis of (-)-7-Epicylindrospermopsin, a Toxic Metabolite of the Freshwater Cyanobacterium Aphanizomenon ovalisporum, and Assignment of Its Absolute Configuration, Computed Properties of 36847-11-7, the main research area is epicylindrospermopsin total synthesis absolute configuration.
The Z and E nitrones II, prepared from condensation of the corresponding aldehyde and hydroxylamine, underwent intramol. dipolar cycloaddition to give substituted 1-aza-7-oxobicyclo[2.2.1] heptanes. Reductive N-O bond cleavage followed by carbonylation gave the cyclic urea in which inversion of the secondary alc. was effected via an oxidation-reduction sequence. After conversion of the p-bromobenzyl ether to the azide, activation of the cyclic urea as its O-methylisourea and reduction of the azide led to spontaneous cyclization to afford the tricyclic nucleus of cylindrospermopsin. Global deprotection, including hydrolysis of the 2,4-dimethoxypyrimidine appendage to a uracil, and then monosulfation of the resultant diol afforded a substance identical with natural (-)-7-epicylindrospermopsin (I). The asym. synthesis of (-)-7-epicylindrospermopsin defines its absolute configuration as 7S,8R,10S,12S,13R,14S.
Journal of Organic Chemistry published new progress about 1,3-Dipolar cycloaddition reaction, stereoselective. 36847-11-7 belongs to class pyrimidines, name is 2,4,6-Tribromopyrimidine, and the molecular formula is C4HBr3N2, Computed Properties of 36847-11-7.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia