Wu, Xiaoai team published research in Bioorganic & Medicinal Chemistry Letters in 2016 | 2927-71-1

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Synthetic Route of 2927-71-1

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Synthetic Route of 2927-71-1.

Wu, Xiaoai;Fang, Zhen;Yang, Bo;Zhong, Lei;Yang, Qiuyuan;Zhang, Chunhui;Huang, Shenzhen;Xiang, Rong;Suzuki, Takayoshi;Li, Lin-Li;Yang, Sheng-Yong research published 《 Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis》, the research content is summarized as follows. Herein the authors report the discovery of a series of new KDM5A inhibitors. A three-dimensional (3D) structure model of KDM5A jumonji domain was firstly established based on homol. modeling. Mol. docking-based virtual screening was then performed against com. chem. databases. A number of hit compounds were retrieved. Further structural optimization and structure-activity relationship (SAR) anal. were carried out to the most active hit compound, (I) (IC50: 2.3 μM), which led to the discovery of several new KDM5A inhibitors. Among them, compound 2-hydrazinylpyrimidine-4-carboxylic acid (15e) is the most potent one with an IC50 value of 0.22 μM against KDM5A. This compound showed good selectivity for KDM5A and considerable ability to suppress the demethylation of H3K4me3 in intact cells. Compound (15e) could be taken as a good lead compound for further studies.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Synthetic Route of 2927-71-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia