In 2018,ChemistrySelect included an article by Xiao, Ke; Zhu, Congjun; Lin, Maohua; Song, Chuanjun; Chang, Junbiao. Formula: C8H10N2O2. The article was titled 《Base-Promoted Cycloisomerization for the Synthesis of Indolizines and Related Heterocycles》. The information in the text is summarized as follows:
The base-mediated 5-exo-dig type cyclization reaction of homopropargyl pyridines for the construction of indolizines I (R1= COOEt, CN, COMe, etc.; R2 = Me, CH2C6H4, 4-ClC6H4CH2, 4-MeOC6H4CH2; R3 = H, 7-Me) has been reported for the first time. A variety of indolizine derivatives could be obtained in moderate to excellent isolated yields by treatment of homopropargyl pryidines with cesium carbonate in DMSO at 100°. This strategy could also be adapted to the synthesis of pyrrolo[1,2-a]quinolines and pyrrolo[1,2-a]pyrimidines from the corresponding homopropargyl quinolines and homopropargyl pyrimidines, resp. The mechanism involves α C-H deprotonation, 5-exo-dig cyclization, and isomerization of the exocyclic double bond to provide the heteroaromatic system. The transformation reported herein does not require the aid of transition metal catalysts or halogens, and is thus environmentally friendly. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3Formula: C8H10N2O2)
Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Formula: C8H10N2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia