《Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities》 was written by Xiao, Ting; Tang, Jia-Fan; Meng, Ge; Pannecouque, Christophe; Zhu, Yuan-Yuan; Liu, Gen-Yan; Xu, Zhi-Qiang; Wu, Feng-Shou; Gu, Shuang-Xi; Chen, Fen-Er. Recommanded Product: 3934-20-1 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:
A series of indazolyl-substituted piperidin-4-yl-aminopyrimidines (IPAPYs) I (R = 2-Cl, 2-Br, 2-CF3, etc.) were designed from two potent HIV-1 NNRTIs piperidin-4-yl-aminopyrimidine and diaryl ether as the lead compounds by mol. hybridization strategy. The target mols. I were synthesized and evaluated for their anti-HIV activities and cytotoxicities in MT-4 cells. I displayed moderate to excellent activities against wild-type (WT) HIV-1 with EC50 values ranging from 1.5 to 0.0064μM. Among them, I (R = 2,6-diMe-4-CN) was regarded as the most excellent compound against WT HIV-1 (EC50 = 6.4 nM, SI = 2500). And also, it displayed potent activities against K103 N (EC50 = 0.077μM), Y181C (EC50 = 0.11μM), E138K (EC50 = 0.057μM), and moderate activity against double mutants RES056 (EC50 = 8.7μM). Moreover, the structure-activity relationships (SARs) were summarized, and the mol. docking was performed to investigate the binding mode of IPAPYs and HIV-1 reverse transcriptase. In the experimental materials used by the author, we found 2,4-Dichloropyrimidine(cas: 3934-20-1Recommanded Product: 3934-20-1)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 3934-20-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia