Xu, Hongtao; Gu, Yuang; Zhang, Shuning; Xiong, Huan; Ma, Fei; Lu, Fengping; Ji, Qun; Liu, Lili; Ma, Peixiang; Hou, Wei; Yang, Guang; Lerner, Richard A. published the artcile< A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries>, COA of Formula: C7H7ClN2O2, the main research area is selenium DNA encoded library preparation; C−H activation; DNA-encoded library; benzoselenazolone; rhodium; selenylation.
Conventional direct C-H selenylation suffers from simple selenation with limited atom economy and complicated reaction system. The authors designed benzoselenazolone as a novel bifunctional selenide reagent for both off- and on-DNA C-H selenylation under rhodium(III) catalysis. Using benzoselenazolone gave a series of selenylation products containing an adjacent aminoacyl group in a fast and efficient way, with high atom economy. The synthetic application of this method was demonstrated by taking advantage of the amide functionality as a nucleophile, directing group, and amide coupling partner. This work shows great potential in facilitating rapid construction of selenium-containing DNA-encoded chem. libraries (SeDELs), and lays the foundation for the development of selenium-containing drugs.
Angewandte Chemie, International Edition published new progress about Azoles Role: RCT (Reactant), RACT (Reactant or Reagent) (benzoselenazolones). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, COA of Formula: C7H7ClN2O2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia