Xu, Ming-Yuan published the artcileMetabolomic biomarkers in urine of rats following long-term low-dose exposure of cadmium and/or chlorpyrifos, COA of Formula: C5H7N3, the main research area is urine metabolomic biomarker cadmium chlorpyrifos exposure; Biomarker; Insecticide; Long-term exposure; Rat; Toxic metal; Urine.
Heavy metals and pesticides can be easily enriched in food chains and accumulated in organisms, thus pose significant threat to human health. However, their combined effects for long-term exposure at low dose has not been thoroughly investigated; especially there was no biofluid biomarker available to noninvasively diagnose the toxicosis of the combined exposure of the two chems. at their low levels. In this study, we investigated the change of urine metabolites of rats with 90-day exposure to heavy metal cadmium (Cd) and/or organophosphorus pesticide chlorpyrifos (CPF) using gas chromatog.-mass spectrometry (GC-MS)-based metabolomics approach. Our results showed that the interaction of Cd and CPF mainly displayed an antagonistic effect. We identified the panels of metabolite biomarkers in urine: benzoic acid and mannose were unique biomarkers for Cd exposure; creatinine and N-phenylacetyl glycine were unique biomarkers for CPF exposure; anthranilic acid, ribitol, and glucose were unique biomarkers for Cd plus CPF exposure. Our results suggest that 90-day exposure to Cd and/or CPF could cause a disturbance in energy and amino acid metabolism And urine metabolomics anal. can help understand the toxicity of low dose exposure to mixed environmental chems.
Ecotoxicology and Environmental Safety published new progress about Biomarkers. 22433-68-7 belongs to class pyrimidines, name is 4-Amino-5-methylpyrimidine, and the molecular formula is C5H7N3, COA of Formula: C5H7N3.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia