On November 4, 2021, Xu, Qing; Li, Zhe; Nilar, Shahul published a patent.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine The title of the patent was Preparation of thienopyrimidines as ferroportin inhibitors. And the patent contained the following:
The invention is related to the preparation of compounds I [R1, R2 = independently H, alkyl, halo, 5- or 6-membered heteroaryl; Z = N, CH; R6 = independently at each occurrence halogen, hydroxy, alkoxy, cycloalkyl, etc.; n = 0-3; Y1 = absent or present; Y1, if present, and Y2, and Y3 = independently selected N, CH, and C (when R6 is attached thereto); R3 = H, alkyl, hydroxyalkyl; R4 = CR4cR4dCONR4aR4b, CH2CH2NR4eR4f, CH2CH2OR4g; R4a = H, alkyl; R4b = H, alkyl, cycloalkyl, 5- to 7-membered heterocyclyl, C6-C10 aryl, and 5- to 10-membered heteroaryl; or NR4aR4b = 5- to 7-membered heterocyclyl; R4c i= H, alkyl, cycloalkyl, hydroxyalkyl; R4d = H, alkyl; or CR4cR4d = cycloalkyl or 5- to 7-membered heterocyclyl; R4e = H, alkyl, C5-C10 cycloalkyl, 5- to 7-membered heterocyclyl, and C6-C10 aryl; R4f = H, alkyl; NR4eR4f = 5- to 7-membered heterocyclyl; R4g = H, alkyl, cycloalkyl, 5- to 7-membered heterocyclyl, C6-C10 aryl, and 5- to 10-membered heteroaryl; wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl of R4b, R4c, R4e, and R4g is optionally substituted with 1-2 substituents; with th e exclusion of a specified compound], and pharmaceutical acceptable salts thereof. Pharmaceutical compositions comprising compounds I, and methods of administering compounds I for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries. Thus, II was prepared from 2,4-dichlorothieno[2,3-d]pyrimidine and Et 2-(methylamino)acetate hydrochloride using 4-methoxy-2-(tributylstannyl)pyridine and 5-amino-2-methoxypyridine.. II was tested in an in vitro ferroportin internalization assay (pEC50 = 6.6). The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine
The Article related to thienopyrimidine preparation ferroportin inhibitor, preparation thienopyrimidine amino acid amide ferroportin inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia