Synthesis of fiacitabine (FIAC) was written by Xu, Shao-hong; Zhang, Wei. And the article was included in Huaxue Shiji on August 15,2011.Formula: C9H12FN3O4 The following contents are mentioned in the article:
Fiacitabine was synthesized from cytidine by protection with Ac2O and selective deprotection with hydrazine hydrate to give 3′,5′-2-O-acetyl-β-D-furanosylcytidine, which was subjected to reaction with diethylaminosulfur trifluoride, deprotection with NH3/CH3OH and then iodination under microwave irradiation with an overall yield of about 42.3%. The structure of product was confirmed by 1HNMR and 13CNMR. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Formula: C9H12FN3O4).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Formula: C9H12FN3O4
56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8