Synthesis and herbicidal activity of 2-aminopyrimidines and their derivatives of 2-thiophenesulfonylureas was written by Xue, Si-Jia;Sun, Chang-You. And the article was included in Hecheng Huaxue in 1998.Application of 1193-74-4 This article mentions the following:
Using Claisen condensation six 灏?dicarbonyl compounds HCOR (R = CH2COCH3, CH(CH3)COCH3, CH2COC6H5), PhCOCH2COCH3, EtCOCH(CH3)COOEt, and 2-formylcyclohexanone were prepared and reacted with guanidine carbonate to give seven 2-aminopyrimidines I (X = CH3, C6H5, OH, Cl; Y = H, C6H5, Et; Z = H, CH3; XZ = (CH2)4). Five N’-(substituted pyrimidin-2-ly)-2-thiophenesulfonylureas II were prepared by nucleophilic addition of 2-aminopyrimidines I with 2-thiophenesulfonyl isocyanate. The structures of substituted 2-aminopyrimidines and their 2-thiophenesulfonylurea derivatives were confirmed by IR,1H NMR and elemental anal., and their herbicidal activities were tested. In the experiment, the researchers used many compounds, for example, 4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4Application of 1193-74-4).
4,5-Dimethylpyrimidin-2-amine (cas: 1193-74-4) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 1193-74-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia