Divergent Solution-Phase Synthesis of Diarylpyrimidine Libraries as Selective A3 Adenosine Receptor Antagonists was written by Yaziji, Vicente;Coelho, Alberto;El Maatougui, Abdelaziz;Brea, Jose;Loza, M. Isabel;Garcia-Mera, Xerardo;Sotelo, Eddy. And the article was included in Journal of Combinatorial Chemistry in 2009.Electric Literature of C16H13N3 This article mentions the following:
A practical and divergent solution-phase synthetic strategy has been optimized to prepare a highly diverse library of 2,4-diaryl- and 2,6-diarylpyrimidines. Structural elaboration of the starting heterocyclic scaffolds was accomplished by exploiting the potential for diversity offered by the Suzuki-Miyaura cross-coupling reaction. These studies enabled the identification of structurally simple, highly potent, and selective A3 adenosine receptor antagonists. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Electric Literature of C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Electric Literature of C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia